Scientists at University of Yale have shown that chains assembled from beta amino-acids, instead than alpha as the one our proteins are built from, can show similar properties.
Frankly, the fact does not strike me as a particularly impressive discovery... But I wonder... what if we were to insert this kind of stuff in our body? Would we be able to create novel enzymes able to act on our own biochemical make-up? Would our enzymes be able to work on it? Now, that would be something... here follows the abstract.
thanks to Coturnix for pointing this out.
High-Resolution Structure of a beta-Peptide Bundle
Douglas S. Daniels, E. James Petersson, Jade X. Qiu, and Alanna Schepartz*
Departments of Chemistry and Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520-8107
alanna.schepartz@yale.edu Received December 4, 2006
Abstract:
We recently reported that beta-peptides can form discrete hetero-oligomers in aqueous solution. Here we describe the structure of such an oligomer as determined by X-ray crystallography. The structure of Zwit-1F reveals a homo-octamer of two cupped "hands" composed of both parallel and antiparallel 314-helices. The core of the assembly is composed entirely of solvent-excluded beta3-homoleucine residues. The Zwit-1F assembly shares many of the physical characteristics of natural proteins.